Scientists have observed a worldwide decline in sperm quality, which is a measure of sperm count, motility, structure, and DNA integrity. Left unchecked, this epidemic could spell massive reductions in the human fertility rate, especially in the industrialized nations where the problem is most acute. Around 40% of infertile men have high levels of free radicals in their semen. This may be due to exposure to environmental toxins, poor diet and unhealthy lifestyle habits such as smoking cigarettes. Sperm also produce high quantities of free radicals as they work hard to traverse the many challenges along their journey to the awaiting egg. It takes a lot of energy to reach the egg. To resolve all of these male factors using a medical approach would require multiple medications—many of them unproven and with substantial side effects. Because of that, women are still the ones who undergo fertility treatments in order to allow men with poor sperm quality to father children—even if they’re not the underlying cause of the problem. However, none of that may be necessary. Many studies have demonstrated that this combination having L-Camitine and Coenzyme Q10 alongwith Astaxanthin, Zinc and Lycopene have a direct impact on sperm quality, potentially avoiding the need for expensive drugs or invasive procedures.


This combination is useful in improving sperms quality by:

  • Increasing the total number of sperm cells produced (sperm count)
  • Improving their physical attributes (morphology)
  • Improving their ability to move properly once ejacuated (motility)
  • Affecting the integrity of their DNA.

Coenzyme Q10

Coenzyme Q10 is a vitamin-like substance that is produced naturally by the body It is present in the membrane of almost every cell in the body and is required for mitochondria! ATP synthesis, which is responsible for creating cellular energy. Scientists believe CoQ10 functions as an antioxidant that blocks actions that can damage cells. Coenzyme Q10 [(CoC10) also commonly called ubiquinone] is present in well-measurable levels in human seminal fluid, where it probably exerts important metabolic and antioxidant functions; seminal CoQ10 concentrations show a direct correlation with seminal parameters (count and motility). Active form of coenzyme Q10 Ubiquinol in the cell membrane may help reduce cell and DNA damage caused by free radicals, which has been shown to reduce blood pressure and improve sperm health and in turn embryo quality. As we age, the ability of the body to produce and metabolize ubiquinone to Ubiquinol declines. In turn so do energy levels and cellular health. CoQ10 deficiency may lead to not only damaged DNA within the sperm, but low levels affect the ability of sperm to swim, known as motility. Ubiquinol supplementation has a twofold support system for sperm health, one it is protective and second it supports motility by increasing cellular energy. The higher the blood levels of CoQ10, the greater the sperm’s ability to be strong swimmers. Defective sperm function in infertile men has been shown to be directly associated with increased free radical stress. This is where Ubiquinol supplementation may greatly help to protect sperm health, as well as the health of all the cells that make up the reproductive organs, and the entire body.


Sperm cells have to travel farther than any other single human cell—and they need a tremendous amount of energy in order to make the trek. That’s what makes carnitine such a vital nutrient for men with poor sperm quality. Camitine is a vital transporter molecule whose function is to carry high-energy fat compounds into mitochondria, where they are “burned” to release their energy. This helps give sperm the boost they need if they are going to have a chance at fertilizing an egg. This is important because weakly-swimming sperm (asthenozoospermia) is one of the most important reasons for male factor infertility. Supplementation with L-camitine has proven benefits on sperm quality. It increases sperm count, motility, straight-swimming ability, as well as total normal sperm forms.


Oxidative stress affects the sperm of men in two different ways: (I) Oxidative stress damages the cell membrane of sperm, which could decrease sperm motility and its ability to connect with an oocyte. (H) Oxidative stress causes damage to the DNA of sperm. This could increase the chance of passing along damaged DNA from the man. Your body has many different ways to protect sperm from oxidative stress. According to clinical research, albumin found in sperm has the potential to block free radicals, which prevents them from reaching the sperm. Also, sperm DNA is tightly covered by a protective protein. And this layer can protect the DNA in your sperm, suggests research, which could prevent damage from occurring to your sperms DNA. However, infertile men could be deficient in this protein, possibly leaving the DNA exposed to reactive oxygen species. One powerful antioxidant, Astaxanthin (a carotenoid extracted from the algae Hematococcus pluvialis), has been shown in research to reduce free radical damage associated with male infertility and significantly increase the sperm’s motility and speed.

Zinc Sulphate Monohydratejj

Zinc deficiency is associated with poor sperm quality resulting from increased oxidant stress in seminal plasma, the liquid portion of semen that is responsible for maintaining sperm cells in a healthy state. Depletion of zinc also reduces the volume of semen produced. Studies in both animal models and humans demonstrate significant improvements in sperm quality following zinc supplementation, especially in cases of known infertility. Supplementation increases sperm counts, mobility, and fertilizing capacity, and decreases levels of DNA damage, structural abnormalities in sperm, and levels of antibodies to sperm that can impair sperm quality. The benefits of zinc supplementation are especially prominent in smokers, whose total body oxidant levels are vastly higher than those of nonsmokers. In addition, smokers accumulate toxic levels of another metal element, cadmium, which accumulates in testicular tissue and further adds to oxidant stress. These effects produce substantial losses of sperm quality and fertility in smokers. Studies show that zinc supplementation reduces the impact of cadmium toxicity and boosts sperm quality in smokers.


Lycopene is a natural, plant-derived carotenoid pigment that provides the red color of tomatoes, watermelon, and other fruits. It has powerful antioxidant characteristics and is involved in a variety of other cellular activities as well. Low intake of lycopene in the diet is associated with poor semen quality and male factor infertility. However, supplementing with lycopene has been shown to reverse some or all of that damage. Another way lycopene enhances sperm quality is by reducing the impact of advanced glycation endproducts (AGEs), the dangerous sugar/protein structures that form over a lifetime of exposure to blood glucose.


Likely Effective for…

  • Coenzyme Q-10 deficiency. Taking coenzyme Q-10 by mouth seems to improve symptoms of coenzyme Q-10 deficiency. This is a very rare condition. The symptoms include weakness, fatigue, and seizures.
  • Inherited or acquired disorders that limit energy production in the cells of the body (mitochondrial disorders). Taking coenzyme Q-10 by mouth seems to reduce symptoms of mitochondrial disorders. However, improvement in symptoms is slow. Some people have to take coenzyme Q-10 for six months to get the most benefit.

Possibly Effective for…

  • Age-related vision loss (age-related macular degeneration). Taking a specific product containing coenzyme Q-10, acetyl-L-carnitine, and omega-3 fatty acids (Phototrop) by mouth seems to improve vision in people with age-related vision loss.
  • Congestive heart failure (CHF). Some research suggests that heart failure might be linked with low coenzyme Q-10 levels. Although most evidence shows that taking coenzyme Q-10 alone does not help treat heart failure, there is some evidence that it might be helpful when taken in combination with other heart failure medications and treatments.
  • Nerve damage caused by diabetes (diabetic neuropathy). Research shows that taking coenzyme Q-10 improves nerve damage and nerve pain in people with nerve damage caused by diabetes.
  • HIV/AIDS. Taking coenzyme Q-10 by mouth seems to improve immune function in people with HIV/AIDS.
  • An inherited neurological disorder called Huntington’s disease. Ubiquinol, an altered form of coenzyme Q-10, has been granted “Orphan Drug Status” by the U.S. Food and Drug Administration (FDA). This gives the maker of Ubiquinol some financial incentives to study its effectiveness for Huntington’s, a condition that is so rare (affecting less than 200,000 individuals) that pharmaceutical companies might not otherwise invest in developing a drug for it. However, taking coenzyme Q-10 by mouth in doses of 600 mg daily or less does not seem to be effective for slowing the progression of Huntington’s disease.
  • High blood pressure. The majority of research shows that taking coenzyme Q-10 by itself or along with other medications for treating high blood pressure seems to help lower blood pressure. However, one small study suggests that taking coenzyme Q-10 by mouth may not lower blood pressure in people that also have a condition called metabolic syndrome.
  • Blood vessel complications caused by heart bypass surgery. Reduced blood supply during heart or blood vessel surgery can deprive tissue of oxygen. When blood supply returns to this tissue, the tissue can become damaged. There is some evidence that taking coenzyme Q-10 by mouth for a week before heart bypass surgery or blood vessel surgery might help to reduce tissue damage. However, not all research agrees with this finding.
  • A specific type of high blood pressure. Taking coenzyme Q-10 daily appears to lower systolic blood pressure (the top number) in some people with high systolic blood pressure but normal diastolic blood pressure (the bottom number).
  • Migraine headache. Taking coenzyme Q-10 by mouth seems to help prevent migraine headaches. Studies show it can decrease the frequency of headaches by about 30% and the number of days with headache-related nausea by about 45% in adults. Taking coenzyme Q-10 also appears to reduce migraine frequency in children who have low levels of coenzyme Q-10. It can take up to 3 months for significant benefit. However, coenzyme Q-10 does not seem to be effective in treating migraines once they have developed.
  • An inherited muscle disorder called muscular dystrophy. Taking coenzyme Q-10 by mouth seems to improve physical performance in some people with muscular dystrophy
  • Heart attack. When started within 72 hours of a heart attack and taken for one year, coenzyme Q-10 appears to lower the risk of heart-related events, including another heart attack.
  • Parkinson’s disease. Some research shows that taking coenzyme Q-10 supplements might slow decline in people with early Parkinson’s disease. However, taking a coenzyme Q-10 does not seem to improve symptoms in people with mid-stage Parkinson’s disease.
  • Peyronie’s disease (painful erection in men). Research shows that taking coenzyme Q-10 improves erectile function in men with painful erections.

Possibly Ineffective for…

  • Alzheimer’s disease. Taking coenzyme Q-10 does not seem to improve mental function in people with Alzheimer’s disease.
  • Neurodegenerative disease called ALS or Lou Gehrid’s disease. Research shows that taking coenzyme Q-10 does not slow the progression of ALS.
  • Cocaine dependence. Taking a combination of coenzyme Q-10 and L-carnitine does not reduce cocaine use.
  • High cholesterol. Some research shows that taking coyenzme Q-10 does not reduce total cholesterol, triglycerides, or low-density lipoprotein (LDL or “bad”) cholesterol, or increase high-density lipoprotein (HDL or “good”) cholesterol. Other research shows that taking coenzyme Q-10 by mouth alone or together with carnitine does not improve cholesterol levels. However, one study in people who can not take statin drugs shows that taking a combination of coenzyme Q-10, berberine, policosanol, red yeast rice, folic acid, and astaxanthin reduces cholesterol levels.
  • Symptoms affecting polio survivors (post-polio syndrome). Research shows that taking coenzyme Q-10 does not improve muscle strength or muscle function in people with post-polio syndrome.

Likely Ineffective for…

  • Athletic performance. Taking coenzyme Q-10 by mouth does not improve althetic performance in athletes or non-athletes.

Insufficient Evidence to Rate Effectiveness for…

  • Chest pain (angina). Some early research suggests that taking coenzyme Q-10 by mouth might improve exercise tolerance in patients with angina.
  • Asthma. Some early research suggests that taking a combination of coenzyme Q-10, vitamin E (alpha-tocopherol), and vitamin C in addition to conventional asthma treatment reduces the dosage of drugs needed by people with mild-to-moderate asthma.
  • Breast cancer. Some research in Chinese women suggests that having low blood levels of coenzyme Q-10 is linked to an increased risk of breat cancer. There is preliminary evidence that taking coenzyme Q-10 by mouth might be helpful in advanced breast cancer when used along with surgery and conventional treatment plus other antioxidants and omega-3 and omega-6 fatty acids.
  • Cancer. Research suggests that low coenzyme Q-10 levels are associated with an increased risk of skin cancer. Also, early research suggests that taking coenzyme Q-10 along with other antioxidants increases survival time by 40% in patients with terminal cancer.
  • Heart toxicity caused by chemotherapy drugs. Some research suggests that taking coenzyme Q-10 by mouth may protect the heart in children and adults receiving the chemotherapy drug anthracycline. However, other research suggests that administering coenzyme Q-10 intravenously (by IV) does not provide this benefit.
  • Lung disease called chronic obstructive pulmonary disease (COPD). Early research suggests that taking coenzyme Q-10 improves lung function and exercise tolerance in people with COPD.
  • Cyclic vomiting syndrome. Some early research suggests that taking coenzyme Q-10 might work as well as prescription medications used to treat cyclic vomiting syndrome.
  • Diabetes. Research about the effectiveness of coenzyme Q-10 for diabetes is conflicting. Some research shows that taking coenzyme Q-10 might lower blood sugar levels. However, other research has found no benefit.
  • Weakend and enlarged heart (dilated cardiomyopathy). Early evidence suggests that taking coenzyme Q-10 improves heart function in children with dilated cardiomyopathy.
  • Dry mouth. Early research suggests that taking coenzyme Q-10 (ubiquinol) improves dry mouth.
  • Eye surgery. Research suggests that administering an eye solution containing coenzyme Q-10 and vitamin E increases the speed of nerve regeneration after cataract eye surgery
  • Fibromyalgia. Some early research suggests that taking coenzyme Q-10 along with ginkgo might increase feelings of wellness and overall health, as well as reduce pain in people with fibromyalgia.
  • Uncoordinated movement due to brain damage (cerebellar ataxia). Early research suggests that coenzyme Q-10 improves muscle coordination and movement in people with cerebellar ataxia.
  • Rare inherited disease that causes nerve damage (Friedreich’s ataxia). Early research suggests that taking vitamin E together with coenzyme Q-10 improves coordination, posture, and movement in people with Friedreich’s ataxia.
  • Hearing loss. Research suggests that taking a specific coenzyme Q-10 product (Q-TER) by mouth improves hearing in people with age-related hearing loss. However, combining coenzyme Q-10 with conventional steroid treatments does not improve hearing more than steroid treatment alone.
  • Hepatitis C. Research shows that taking coenzyme Q-10 does not improve liver function in people with hepatitis C who are not responding to conventional treatment.
  • A heart condition called hypertrophic cardiomyopathy. Taking coenzyme Q-10 by mouth seems to decrease the thickness of the heart wall and decrease symptoms of shortness of breath and fatigue in people with hypertrophic cardiomyopathy.
  • Rare genetic disorder called Prader-Willi syndrome. Early research suggests that administering coenzyme Q-10 improves development in children with Prader-Labhart-Willi syndrome. However, it is not clear if these improvements are due to the coenzyme Q-10 or an age-related phenomenon.
  • Male infertility. There is some early evidence that coenzyme Q-10 treatment can improve the movement and density of sperm in men with certain types of infertility. However, other research shows that it does not have a beneficial effect on sperm movement.
  • Inherited diabetes and deafness. There is some early evidence that taking coenzyme Q-10 by mouth might prevent the progression of a rare form of diabetes that is maternally inherited.
  • Gum disease. Applying coenzyme Q-10 to the gums is not effective for treating gum disease. However, there is some early evidence that taking coenzyme Q-10 by mouth might be helpful in treating gum disease.
  • High blood pressure during pregnancy (pre-eclampsia). Pre-eclampsia is a condition that some women develop during pregnancy. Some research shows that women who are at risk have a lower chance of developing the condition if they take coenzyme Q-10 from week 20 of pregnancy until the baby is delivered
  • Prostate cancer. Research shows that taking a combination of vitamin E, selenium, vitamin C, and coenzyme Q-10 does not improve prostate cancer.
  • Kidney failure. Some early research suggests that taking coenzyme Q-10 improves kidney function in people with end-stage kidney disease. However, other research shows that taking coenzyme Q-10 does not improve kidney function.
  • A muscle condition called “statin-induced myopathy.” Statins, a class of drugs used to lower cholesterol, can sometimes cause muscle pain. There is some evidence that taking coenzyme Q-10 might reduce this pain. However, not all evidence has been positive.
  • Hair loss related to use of the warfarin. There is some early evidence that taking coenzyme Q-10 might be helpful for preventing hair loss caused by the blood-thinning drug, warfarin.
  • Wrinkled skin. Early evidence suggests that applying a coenzyme Q-10 cream to the skin improves wrinkled skin.
  • Fatigue.
  • Lyme disease.
  • Other conditions.

More evidence is needed to rate coenzyme Q-10 for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


Coenzyme Q-10 is LIKELY SAFE for most adults when taken by mouth or when applied directly to the gums. While most people tolerate coenzyme Q-10 well, it can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. It can cause allergic skin rashes in some people. It also might lower blood pressure, so check your blood pressure carefully if you have very low blood pressure. Dividing the total daily dose by taking smaller amounts two or three times a day instead of a large amount all at once can help reduce side effects.

Coenzyme Q-10 is POSSIBLY SAFE for children when taken by mouth. However, coenzyme Q-10 should not be used in children without medical supervision.